This two‐part Review examines how automation has contributed to different aspects of
discovery in the chemical sciences. In this first part, we describe a classification for …

DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …

Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by
empowering combinatorial library synthesis with a “few good reactions”. These click …

DNA-encoded library (DEL) technology is a powerful tool commonly used by the
pharmaceutical industry for the identification of compounds with affinity to biomolecular …

Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in
necroptosis and a potential target to control inflammatory disease. Here, three selective …

Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate
chains that endow articular cartilage with its ability to withstand compressive loads. It is …

In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …

It is currently widely accepted among clinicians that chronic tendinopathy is caused by a
degenerative process devoid of inflammation. Current treatment strategies are focused on …

DNA-encoded library technology (DELT) was introduced to our medicinal chemistry society
more than 20 years ago. The application of DELT in the development of clinical candidates …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …