Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells

MD Flood, ED Eggers - Journal of Neurophysiology, 2021 - journals.physiology.org
The adaptation of ganglion cells to increasing light levels is a crucial property of the retina.
The retina must respond to light intensities that vary by 10–12 orders of magnitude, but the …

Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin

JD Deming, J Shin, K Lim, EJ Lee… - Cellular signalling, 2015 - Elsevier
Purpose The G-protein coupled receptor (GPCR) Dopamine Receptor D4 (DRD4) plays an
essential role in cAMP regulation and gap junctional coupling in the photoreceptors, where …

Cone Arrestin 4 Contributes to Vision, Cone Health, and Desensitization of the Dopamine Receptor D4

JD Deming - 2015 - search.proquest.com
In this dissertation, I investigated classical and alternative roles of Cone Arrestin 4 (ARR4).
First, my collaborators and I described visual phenotypes of Arr4 null mice. Subsequently …