The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …

The generation of human sensory neurons by directed differentiation of pluripotent stem
cells opens new opportunities for investigating the biology of pain. The inability to generate …

Background The pathogenesis of neuropathic pain and the reasons for the prolonged
unhealing remain unknown. Increasing evidence suggests that sex oestrogen differences …

Potentially noxious stimuli are sensed by specialized nerve cells named nociceptors, which
convey nociceptive signals from peripheral tissues to the central nervous system. The spinal …

Primary pain and touch sensory neurons not only detect internal and external sensory
stimuli, but also receive inputs from other neurons. However, the neuronal derived inputs for …

The GABA ergic system is the main inhibitory neurotransmitter system in the central nervous
system (CNS) of vertebrates. Signalling of the transmitter γ‐aminobutyric acid (GABA) via …

Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic
pain. Apparently contradictory mechanisms have been reported, raising questions on the …

Bacterial products can act on neurons to alter signaling and function. In the present study,
we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the …