There are several cellular and acellular structural barriers associated with the brain
interfaces, which include the dura, the leptomeninges, the perivascular space and the …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of
long-term outcome remains a major challenge. Here, we investigate five myeloid markers …

Mammalian brain border-associated macrophages (BAMs) are strategically positioned to
support vital properties and processes: for example, the composition of the brain's …

The effectiveness of tumor therapy, especially immunotherapy and oncolytic virotherapy,
critically depends on the activity of the host immune cells. However, various local and …

Glioblastoma (GBM) is the most malignant and lethal intracranial tumor with extremely
limited treatment options. Recognizing the pronounced heterogeneity in the prognosis of …

Brain resident macrophages such as microglia and CNS-associated macrophages (CAMs)
are already established before birth and play therefore a crucial role for normal brain …