Emerging investigator series: interactions of engineered nanomaterials with the cell plasma membrane; what have we learned from membrane models?

AM Farnoud, S Nazemidashtarjandi - Environmental Science: Nano, 2019 - pubs.rsc.org
With the increasing industrial and biomedical applications of engineered nanomaterials
(ENMs), concerns have been raised regarding the increased risk of exposure. Exposure to …

[HTML][HTML] The influence of curvature on the properties of the plasma membrane. Insights from atomistic molecular dynamics simulations

SO Yesylevskyy, T Rivel, C Ramseyer - Scientific reports, 2017 - nature.com
In this work we conduct a systematic analysis of the influence of curvature on various
properties of a realistic model of mammalian plasma membrane with asymmetric lipid …

[HTML][HTML] Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives

P Pengo, M Şologan, L Pasquato, F Guida… - European Biophysics …, 2017 - Springer
Molecular self-assembly is a topic attracting intense scientific interest. Various strategies
have been developed for construction of molecular aggregates with rationally designed …

[HTML][HTML] Preparation of artificial plasma membrane mimicking vesicles with lipid asymmetry

Q Lin, E London - PloS one, 2014 - journals.plos.org
Lipid asymmetry, the difference in lipid distribution across the lipid bilayer, is one of the most
important features of eukaryotic cellular membranes. However, commonly used model …

Clear and present danger? Engineered nanoparticles and the immune system

B Fadeel - Swiss medical weekly, 2012 - smw.ch
The innate immune system is the first line of defense against microbial invasion and involves
the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition …

The ins and outs of lipid flip-flop

JS Allhusen, JC Conboy - Accounts of chemical research, 2017 - ACS Publications
Conspectus Our current view of cellular membranes centers on the fluid-mosaic model,
which envisions the cellular membrane as a “liquidlike” bilayer of lipids, cholesterol, and …

Specific interactions of peripheral membrane proteins with lipids: what can molecular simulations show us?

AH Larsen, LH John, MSP Sansom… - Bioscience …, 2022 - portlandpress.com
Peripheral membrane proteins (PMPs) can reversibly and specifically bind to biological
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …

Giant plasma membrane vesicles: models for understanding membrane organization

KR Levental, I Levental - Current topics in membranes, 2015 - Elsevier
The organization of eukaryotic membranes into functional domains continues to fascinate
and puzzle cell biologists and biophysicists. The lipid raft hypothesis proposes that collective …

Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer …

BF Iglesias-Figueroa, TS Siqueiros-Cendón… - Apoptosis, 2019 - Springer
Breast cancer is the most frequently diagnosed cancer among women worldwide. Here,
recombinant human lactoferrin (rhLf) expressed in Pichia pastoris was tested for its potential …

[HTML][HTML] Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation

V Vásquez, M Krieg, D Lockhead, MB Goodman - Cell reports, 2014 - cell.com
Mechanoelectrical transduction (MeT) channels embedded in neuronal cell membranes are
essential for touch and proprioception. Little is understood about the interplay between …