Liquid–liquid phase separation as an organizing principle of intracellular space: Overview of the evolution of the cell compartmentalization concept

IA Antifeeva, AV Fonin, AS Fefilova… - Cellular and Molecular …, 2022 - Springer
At the turn of the twenty-first century, fundamental changes took place in the understanding
of the structure and function of proteins and then in the appreciation of the intracellular …

Liquid phase partitioning in virus replication: observations and opportunities

C Wu, AS Holehouse, DW Leung… - Annual Review of …, 2022 - annualreviews.org
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

[HTML][HTML] Phase separation of FSP1 promotes ferroptosis

T Nakamura, C Hipp, A Santos Dias Mourão… - Nature, 2023 - nature.com
Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour
entities including therapy-refractory and dedifferentiating cancers,–. Recently, ferroptosis …

Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

C Wang, M Terrigno, J Li, T Distler, NJ Pandya… - Neuron, 2023 - cell.com
Many RNA-binding proteins (RBPs), particularly those associated with RNA granules,
promote pathological protein aggregation in neurodegenerative diseases. Here, we …

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

G Limorenko, M Tatli, R Kolla, S Nazarov… - Nature …, 2023 - nature.com
Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative
diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in …

Liquid–liquid phase separation in plants: Advances and perspectives from model species to crops

Q Liu, W Liu, Y Niu, T Wang, J Dong - Plant Communications, 2024 - cell.com
Membraneless biomolecular condensates play important roles in both normal biological
activities and responses to environmental stimuli in living organisms. Liquid‒liquid phase …

Tau; one protein, so many diseases

P Tabeshmehr, E Eftekharpour - Biology, 2023 - mdpi.com
Simple Summary Tau is an important protein for maintaining the shape and normal function
of nerve cells. There are many diseases that are identified by changes in this protein, yet …

Distinct effects of familial Parkinson's disease-associated mutations on α-synuclein phase separation and amyloid aggregation

B Xu, F Fan, Y Liu, Y Liu, L Zhou, H Yu - Biomolecules, 2023 - mdpi.com
The Lewy bodies and Lewy neurites are key pathological hallmarks of Parkinson's disease
(PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) …

Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …

[HTML][HTML] Liquid− liquid phase separation of tau: driving forces, regulation, and biological implications

P Li, J Chen, X Wang, Z Su, M Gao, Y Huang - Neurobiology of Disease, 2023 - Elsevier
The past 15 years have witnessed an explosion in the studies of biomolecular condensates
that are implicated in numerous biological processes and play vital roles in human health …