[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

An update on the molecular and cellular basis of pharmacotherapy in type 2 diabetes mellitus

MO Mahgoub, II Ali, JO Adeghate, K Tekes… - International journal of …, 2023 - mdpi.com
Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than
537 million cases of diabetes were reported worldwide in 2021, and the number is steadily …

How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk

I Camaya, B O'Brien, S Donnelly - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes is the fastest growing chronic disease globally, with prevalence increasing at a
faster rate than heart disease and cancer. While the disease presents clinically as chronic …

Sarcopenia in a type 2 diabetic state: reviewing literature on the pathological consequences of oxidative stress and inflammation beyond the neutralizing effect of …

N Muvhulawa, SE Mazibuko-Mbeje, D Ndwandwe… - Life Sciences, 2023 - Elsevier
Sarcopenia remains one of the major pathological features of type 2 diabetes (T2D),
especially in older individuals. This condition describes gradual loss of muscle mass …

Gut microbiota targeted approach by natural products in diabetes management: An overview

P Sati, P Dhyani, E Sharma, DC Attri, A Jantwal… - Current Nutrition …, 2024 - Springer
Abstract Purpose of Review This review delves into the complex interplay between obesity-
induced gut microbiota dysbiosis and the progression of type 2 diabetes mellitus (T2DM) …

Global Trends in Risk Factors and Therapeutic Interventions for People with Diabetes and Cardiovascular Disease: Results from the WHO International Clinical Trials …

M Ndlovu, PV Dludla, N Muvhulawa, Y Ntamo… - Diabetology, 2023 - mdpi.com
This study presents a comprehensive analysis of 898 clinical trials conducted between 1999
and 2023, focusing on the interplay of metabolic syndrome, cardiovascular diseases …

Lactoferrin decorated bilosomes for the oral delivery of quercetin in type 2 diabetes: In vitro and in vivo appraisal

MO Soliman, AH El-Kamel, MG Shehat, BA Bakr… - International Journal of …, 2023 - Elsevier
Despite its tremendous potential for type 2 diabetes management, quercetin (QRC) suffers
poor gastric stability, poor bioavailability, and extensive first pass metabolism. Drug …

Preservation of β-Cells as a Therapeutic Strategy for Diabetes

J Taneera, MM Saber-Ayad - Hormone and Metabolic …, 2024 - thieme-connect.com
The preservation of pancreatic islet β-cells is crucial in diabetes mellitus, encompassing
both type 1 and type 2 diabetes. β-cell dysfunction, reduced mass, and apoptosis are central …

Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets

O Banerjee, S Singh, T Paul, BK Maji, S Mukherjee - Scientific Reports, 2024 - nature.com
Bisphenol-A (BPA) is widely used in food packaging and household products, leading to
daily human exposure and potential health risks including metabolic diseases like type 2 …

The Potential of the Adzuki Bean (Vigna angularis) and Its Bioactive Compounds in Managing Type 2 Diabetes and Glucose Metabolism: A Narrative Review

SH Kwan, E Gonzalez de Mejia - Nutrients, 2024 - mdpi.com
Type 2 diabetes (T2D) is a common noncommunicable disease. In the United States alone,
37 million Americans had diabetes in 2017. The adzuki bean (Vigna angularis), a legume …