NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …

Chemotherapy drugs such as vincristine (Vin) could cause neuropathic pain. However, it is
still lack of ideal therapeutic strategy to treat it. Mitochondrial dysfunction has been involved …

In this article, we propose that differences in COVID-19 morbidity may be associated with
transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 …

Fulminant hepatitis (FH) is a severe liver disease characterized by extensive hepatic
necrosis, oxidative stress, and inflammation. Myricetin (Myr), a botanical flavonoid glycoside …

Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI),
characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage …

Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative
stress. The present study examines the mechanisms underlying the protective effect of …

Intracerebral hemorrhage (ICH) is a subtype of stroke with a high mortality rate. Oxidative
stress cascades play an important role in brain injury after ICH. Cannabidiol, a major non …

Corilagin (Cori) possesses multiple biological activities. To determine whether Cori can
exert protective effects against nonalcoholic fatty liver disease (NAFLD) and its potential …

Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of
diverse liver diseases. However, treatment choice for immune-mediated hepatic injury …

Activation of hepatic stellate cells (HSCs) constitutes a crucial etiological factor leading to
liver fibrosis. Theaflavine (TF) is a characteristic bioactive compound in fermented tea. Here …