NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

The gut microbiota drives individual sensitivity to excess acetaminophen (APAP)-mediated
hepatotoxicity. It has been reported that the bacterium Akkermansia muciniphila protects …

Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …

Mitochondria play an essential role in bioenergetics and respiratory functions for cell viability
through numerous biochemical processes. To maintain mitochondria quality control and …

Corilagin, a gallotannin, shows excellent antioxidant and anti‐inflammatory effects. The
NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation …

Oxidative/nitrosative stress is proposed to be a critical factor in various diseases, including
liver pathologies. Antioxidants derived from medicinal plants have been studied extensively …

Oxidative stress and inflammation play an important role in the pathophysiological changes
of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor …

Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …

NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …