Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Cell death and inflammation are closely linked arms of the innate immune response to
combat infection and tissue malfunction. Recent advancements in our understanding of the …

Tumor necrosis factor (TNF) plays a central role in orchestrating mammalian inflammatory
responses. It promotes inflammation either directly by inducing inflammatory gene …

The intestinal vasculature has been studied for the last 100 years, and its essential role in
absorbing and distributing ingested nutrients is well known. Recently, fascinating new …

The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

The success of a prosthetic treatment is closely related to the periodontal health of the
individual. The aim of this article was to review and present the importance of prosthetic …

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the
TNF superfamily of receptor ligands. The cytokine exists as either a transmembrane or a …

Background Inflammation is critical in the pathophysiology of atherosclerosis (AS). The aim
of this study was to investigate the protective effect of salvianolic acid B (Sal B) on AS and to …

Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …

The intestinal epithelium is a single cell layer that is constantly renewed and acts as a
physical barrier that separates intestinal microbiota from underlying tissues. In inflammatory …