Prolyl oligopeptidase (POP), also called prolyl endopeptidase, is a cytosolic enzyme
investigated by several research groups. It has been proposed to play an important role in …

In Canada, the use of botanical natural health products (NHPs) for anxiety disorders is on
the rise, and a critical evaluation of their safety and efficacy is required. The purpose of this …

Natural products have gained popularity worldwide for promoting healthcare, as well as
disease prevention. Medical use of alkaloid-containing plants has a long history and many …

Black cohosh preparations are popular dietary supplements among women seeking
alternative treatments for menopausal complaints. For decades, triterpene glycosides and …

The California poppy (Eschscholzia californica Cham.) contains a variety of natural
compounds including several alkaloids found exclusively in this plant. Because of the …

Eighteen alkaloids were detected in the bark, leaves, wood and roots of Peumus boldus,
including traces of secoboldine, N-methylsecoboldine (boldine methine), glaucine and …

The placental passage of protopine was investigated with a human ex vivo placental
perfusion model. The model was first validated with diazepam and citalopram, 2 compounds …

Benzylisoquinoline alkaloids (BIAs) have profound implications on human health owing to
their potent pharmacological properties. Notable naturally occurring BIAs are the narcotic …

Like many effective therapeutics, interleukin-12 (IL-12) therapy often causes side effects.
Tumor targeted delivery may improve the efficacy and decrease the toxicity of systemic IL-12 …

Cancer is a disease that involves impaired genome stability with a high mortality index
globally. Since its discovery, many have searched for effective treatment, assessing different …