The dynamic spatial organization of genomes across time, referred to as the four-
dimensional nucleome (4DN), is a key component of gene regulation and biological fate …

Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …

Understanding the complexity of the long-lived HIV reservoir during antiretroviral therapy
(ART) remains a considerable impediment in research towards a cure for HIV. To address …

Host restriction factors play key roles in innate antiviral defense, but it remains poorly
understood which of them restricts HIV-1 in vivo. Here, we used single-cell transcriptomic …

The polymerase-associated factor 1 complex (PAF1C) is a key, post-initiation transcriptional
regulator of both promoter-proximal pausing and productive elongation catalyzed by RNA …

HIV-1 integration introduces ectopic transcription factor binding sites into host chromatin. We
postulate that the integrated provirus serves as an ectopic enhancer that recruits additional …

Summary Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4
(CTLA4) suppress CD4+ T cell activation and may promote latent HIV infection. By …

HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist
in anatomically distinct latent reservoirs. The contribution of genome organization in HIV-1 …

Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping
mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new …

The retrovirus HIV‐1 integrates into the host genome and establishes a latent viral reservoir
that escapes immune surveillance. Molecular mechanisms of HIV‐1 latency have been …