Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

The appearance of multicellular organisms imposed the development of several
mechanisms for cell-to-cell communication, whereby different types of cells coordinate their …

High-resolution spatial transcriptomics enables mapping of RNA expression directly from
intact tissue sections; however, its utility for the elucidation of disease processes and …

Aims: Inflammasome activation plays a pivotal role in many inflammatory diseases. Given
that connexin (Cx) channels regulate numerous cellular events leading to inflammasome …

It has long been known that the main secretory cells of exocrine and endocrine glands are
connected by gap junctions, made by a variety of connexin species that ensure their …

The protease renin, the key enzyme of the renin–angiotensin–aldosterone system, is mainly
produced and secreted by juxtaglomerular cells in the kidney, which are located in the walls …

Although macula densa (MD) cells are chief regulatory cells in the nephron with unique
microanatomical features, they have been difficult to study in full detail due to their …

We investigated the potential involvement of connexin hemichannels in cadmium ions
(Cd2+)-elicited cell injury. Transfection of LLC-PK1 cells with a wild-type connexin43 (Cx43) …

In the pharmacological treatment of prostate cancer, benign prostatic hyperplasia and
androgenetic alopecia finasteride is commonly used. This drug inhibits 5α-reductase type 2 …