Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the …

A Padmanabhan, L Connelly‐Smith… - Journal of clinical …, 2019 - Wiley Online Library
ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating and categorizing …

Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

H Scholz, FJ Boivin, KM Schmidt-Ott… - Nature Reviews …, 2021 - nature.com
Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Plants as sources of anti-inflammatory agents

CR Nunes, M Barreto Arantes… - Molecules, 2020 - mdpi.com
Plants represent the main source of molecules for the development of new drugs, which
intensifies the interest of transnational industries in searching for substances obtained from …

[HTML][HTML] Characteristics and mechanism of liver injury in 2019 coronavirus disease

J Li, JG Fan - Journal of clinical and translational hepatology, 2020 - ncbi.nlm.nih.gov
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
(2019 coronavirus disease, COVID-19) since December 2019, from Wuhan, China, has …

Blood-brain barrier disruption by lipopolysaccharide and sepsis-associated encephalopathy

X Peng, Z Luo, S He, L Zhang, Y Li - Frontiers in cellular and infection …, 2021 - frontiersin.org
As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis

K Zhang, Y Wang, S Chen, J Mao, Y Jin, H Ye… - Nature …, 2023 - nature.com
Sepsis-induced cardiomyopathy (SICM) is common in septic patients with a high mortality
and is characterized by an abnormal immune response. Owing to cellular heterogeneity …

Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis

Y Chen, R Luo, J Li, S Wang, J Ding, K Zhao, B Lu… - Acs Nano, 2022 - ACS Publications
Sepsis, a life-threating illness caused by deregulated host immune responses to infections,
is characterized by overproduction of multiple reactive oxygen and nitrogen species (RONS) …

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

JM Cavaillon, M Singer, T Skirecki - EMBO molecular medicine, 2020 - embopress.org
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …