Early‐life stress induces anxiety‐like behaviors and activity imbalances in the medial prefrontal cortex and amygdala in adult rats

J Ishikawa, R Nishimura… - European Journal of …, 2015 - Wiley Online Library
Early‐life stress increases the prevalence of psychiatric diseases associated with emotional
dysregulation. Emotional regulation requires the inhibitory influence of the medial prefrontal …

Long‐term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy

J Desloovere, P Boon, LE Larsen, C Merckx… - …, 2019 - Wiley Online Library
Objective More than one‐third of patients with temporal lobe epilepsy (TLE) continue to have
seizures despite treatment with antiepileptic drugs, and many experience severe drug …

[HTML][HTML] The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation

JJ Burston, AM Valdes, SG Woodhams, PI Mapp… - Pain, 2019 - journals.lww.com
Anxiety and depression are associated with increased pain responses in chronic pain
states. The extent to which anxiety drives chronic pain, or vice versa, remains an important …

Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD

I Raony, I Domith, MV Lourenco… - Progress in Neuro …, 2022 - Elsevier
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has
recently been implicated in several psychiatric conditions related to monoaminergic …

Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems

T Archer, D Garcia - Neurotoxin Modeling of Brain Disorders—Life-long …, 2016 - Springer
Attention-deficit/hyperactivity disorder (ADHD) pathophysiology persists in an obscure
manner with complex interactions between symptoms, staging, interventions, genes, and …

Genetically determined differences in noradrenergic function: The spontaneously hypertensive rat model

TL Sterley, FM Howells, VA Russell - Brain Research, 2016 - Elsevier
While genetic predisposition is a major factor, it is not known how development of attention-
deficit/hyperactivity disorder (ADHD) is modulated by early life stress. The spontaneously …

Anxiety correlates with somatic symptoms and sleep status at high altitudes

J Dong, J Zhang, J Qin, Q Li, W Huang, X Gao, J Yu… - Physiology & …, 2013 - Elsevier
High altitude exposure results in many physical and psychological discomforts, with anxiety
and sleep disturbances being the most common ones. This cross-sectional study was …

Early ethanol exposure and vinpocetine treatment alter learning‐and memory‐related proteins in the rat hippocampus and prefrontal cortex

PC Swart, CB Currin, VA Russell… - Journal of …, 2017 - Wiley Online Library
This study investigates the effects of early exposure to ethanol on cognitive function and
neural plasticity‐related proteins in the rat brain. Sprague‐Dawley rats were administered …

Evidence for reduced tonic levels of GABA in the hippocampus of an animal model of ADHD, the spontaneously hypertensive rat

TL Sterley, FM Howells, VA Russell - Brain research, 2013 - Elsevier
Recent studies have investigated the role of γ-aminobutyric acid (GABA) in the behavioural
symptoms of attention-deficit/hyperactivity disorder (ADHD), specifically in behavioural …

The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats

T Cao, L Wang, SM Jiao, H Chen, CQ Lin… - …, 2023 - karger.com
Introduction: Progesterone receptor component 1 (PGRMC1) has been identified as a
potential target in atypical antipsychotic drug-induced metabolic disturbances as well as …