Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …

Pericellular proteolysis is a hallmark of tumor cell metastasis. The membrane type (MT)-
matrix metalloproteinases (MMPs) constitute a distinctive group of membrane-bound MMPs …

Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach
to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to …

The process of cancer cell invasion involves degradation of the extracellular matrix (ECM)
by proteases, integrin adhesion and cell motility. The role of ECM degrading proteases on …

Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate,
acquire the ability to proliferate, and invade the extracellular matrix. In addition, Id-1 is …

Genetic alterations of APC and CTNNB1 (β-catenin) have been identified in a number of
human cancers including tumors arising in the colon and liver. Mutations in these genes …

Abstract Introduction Matrix metalloproteinase (MMP)-2 is very active at degrading
extracellular matrix. It is under the influence of an activator, membrane type 1 MMP (MMP …

Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation:
role of receptor glycoproteins - PMC Back to Top Skip to main content NIH NLM Logo Access …

The restricted view of matrix metalloproteinases (MMPs) as simple destroyers of
extracellular matrix components has largely ignored their substantial contribution in many …

In normal breast and ductal carcinoma in situ, myoepithelial cells form an incomplete layer
separating the epithelial compartment from the stromal environment. Transition to invasive …