Recent advances on quinazoline derivatives: A potential bioactive scaffold in medicinal chemistry

R Karan, P Agarwal, M Sinha, N Mahato - ChemEngineering, 2021 - mdpi.com
This paper intended to explore and discover recent therapeutic agents in the area of
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …

Advances in Palladium‐Catalyzed Decarboxylative Cycloadditions of Cyclic Carbonates, Carbamates and Lactones

Y You, Q Li, YP Zhang, JQ Zhao, ZH Wang… - …, 2022 - Wiley Online Library
Palladium‐catalyzed decarboxylative cycloadditions have emerged as highly effective
methods for constructing structurally diverse carbo‐and heterocycles because of the …

Identification of unique quinazolone thiazoles as novel structural scaffolds for potential gram-negative bacterial conquerors

J Wang, MF Ansari, CH Zhou - Journal of Medicinal Chemistry, 2021 - ACS Publications
A class of quinazolone thiazoles was identified as new structural scaffolds for potential
antibacterial conquerors to tackle dreadful resistance. Some prepared compounds exhibited …

Design, synthesis, computational study and cytotoxic evaluation of some new quinazoline derivatives containing pyrimidine moiety

S Zare, L Emami, Z Faghih, F Zargari, Z Faghih… - Scientific reports, 2023 - nature.com
Quinazoline derivatives, as an important category of heterocyclic compounds, have received
much attention for the design and development of new drugs due to their various …

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

F Oyoun, A Toncheva, LC Henríquez… - …, 2023 - Wiley Online Library
In the spirit of circular economy and sustainable chemistry, the use of environmentally
friendly chemical products in pharmacy has become a hot topic. In recent years, organic …

Medicinal chemistry of quinazolines as anticancer agents targeting tyrosine kinases

MF Zayed - Scientia Pharmaceutica, 2023 - mdpi.com
Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors

MS Raghu, HA Swarup, T Shamala, BS Prathibha… - Heliyon, 2023 - cell.com
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …

A 1, 2, 3-Triazole derivative of quinazoline exhibits antitumor activity by tethering RNF168 to SQSTM1/P62

FC Wang, B Peng, TT Ren, SP Liu, JR Du… - Journal of Medicinal …, 2022 - ACS Publications
Quinazoline and its derivatives have drawn much attention in the development of potential
antitumor agents. Here, we synthesized a series of 1, 2, 3-triazole derivatives of quinazoline …

Recent advances in the synthesis of 2, 3-fused quinazolinones

W Wang, PS Zou, L Pang, CX Pan, DL Mo… - Organic & Biomolecular …, 2022 - pubs.rsc.org
As one of the most important structural units in pharmaceuticals and medicinal chemistry,
quinazolinone and its derivatives exhibit a wide range of biological and pharmacological …

Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles

B Borah, LR Chowhan - RSC advances, 2022 - pubs.rsc.org
Heterocycles of synthetic and natural origin are a well-established class of compounds
representing a broad range of organic molecules that constitute over 60% of drugs and …