Melatonin receptor structure and signaling

HH Okamoto, E Cecon, O Nureki… - Journal of Pineal …, 2024 - Wiley Online Library
Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

The role of melatonin to ameliorate oxidative stress in sperm cells

A Makris, AI Alevra, A Exadactylos… - International Journal of …, 2023 - mdpi.com
It is widely accepted that oxidative stress (OS) coming from a wide variety of causes has
detrimental effects on male fertility. Antioxidants could have a significant role in the treatment …

Melatonin in sperm biology: Breaking paradigms

JA Cebrián‐Pérez, A Casao… - … in Domestic Animals, 2014 - Wiley Online Library
Contents Melatonin is a ubiquitous molecule, present in a wide range of organisms, and
involved in multiple functions. Melatonin relays the information about the photoperiod to the …

Melatonin and periodontal tissues: Molecular and clinical perspectives

AR Carpentieri, MEP Lopez, J Aguilar… - Pharmacological Research, 2017 - Elsevier
Periodontal disease is a frequent chronic inflammatory pathology that implies the destruction
of the tissues supporting the teeth, which represents a high sanitary cost. It usually appears …

[HTML][HTML] Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin's roles in prophylaxis and management

AY Onaolapo, OJ Onaolapo - World journal of diabetes, 2018 - ncbi.nlm.nih.gov
Diabetes mellitus is a chronic, life-threatening metabolic disorder that occurs worldwide.
Despite an increase in the knowledge of the risk factors that are associated with diabetes …

Melatonin, adolescence, and the brain: An insight into the period‐specific influences of a multifunctional signaling molecule

OJ Onaolapo, AY Onaolapo - Birth defects research, 2017 - Wiley Online Library
Melatonin is a neurohormone that is involved in the modulation of a wide range of
physiological processes, including maintenance of the circadian rhythm, mediation of …

Melatonin and ubiquitin: what's the connection?

J Vriend, RJ Reiter - Cellular and Molecular Life Sciences, 2014 - Springer
Melatonin has been widely studied for its role in photoperiodism in seasonal breeders; it is
also a potent antioxidant. Ubiquitin, a protein also widespread in living cells, contributes to …

Homo sapiens May Incorporate Daily Acute Cycles of “Conditioning–Deconditioning” to Maintain Musculoskeletal Integrity: Need to Integrate with Biological Clocks …

DA Hart, RF Zernicke, NG Shrive - International Journal of Molecular …, 2022 - mdpi.com
Human evolution required adaptation to the boundary conditions of Earth, including 1 g
gravity. The bipedal mobility of Homo sapiens in that gravitational field causes ground …

The Plasmodium falciparum eIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on …

BKM Dias, M Nakabashi, MRR Alves… - Journal of Pineal …, 2020 - Wiley Online Library
Melatonin and its indoles derivatives are central in the synchronization of malaria parasites.
In this research, we discovered that melatonin is unable to increase the parasitemia in the …

[HTML][HTML] Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone

A Sotthibundhu, K Ekthuwapranee, P Govitrapong - EXCLI journal, 2016 - ncbi.nlm.nih.gov
Melatonin, secreted mainly by the pineal gland, plays roles in various physiological
functions including protecting cell death. We showed in previous study that the proliferation …