Bacteria secrete small molecules known as siderophores to acquire iron from their
surroundings. For over 60 years, investigations into the bioinorganic chemistry of these …

Host inflammation alters the availability of nutrients such as iron to limit microbial growth.
However, Salmonella enterica serovar Typhimurium thrives in the inflamed gut by …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …

High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority
of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been …

The global crisis of untreatable microbial infections necessitates the design of new
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune
response. The current working model states that CP sequesters manganese and zinc from …

Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Lanmodulin (LanM) is a recently discovered protein that undergoes a large conformational
change in response to rare-earth elements (REEs). Here, we use multiple physicochemical …