Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and
novel treatments are urgently needed. Current therapeutic approaches for diabetic …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Loss of podocytes underlies progression of CKD. Detachment of podocytes from the
glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the …

The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …

The glomerular filtration barrier in the kidney is formed in part by a specialized intercellular
junction known as the slit diaphragm, which connects adjacent actin-based foot processes of …

Podocyte dysfunction plays an essential role in the pathogenesis of proteinuria and
glomerulosclerosis. However, the mechanism underlying podocyte dysfunction in many …

In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …

A properly established and maintained podocyte intercellular junction, or slit diaphragm, is a
necessary component of the selective permeability barrier of the kidney glomerulus. The …

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of
biological activities, including mechanosensation, osmotic homeostasis, and cell signaling …

From recent data, a novel concept of a highly dynamic slit protein complex is emerging. Slit
diaphragm proteins are contributing to the regulation of cell polarity, cell survival and …