Diabetic nephropathy: perspective on novel molecular mechanisms
L Gnudi, RJM Coward, DA Long - Trends in Endocrinology & Metabolism, 2016 - cell.com
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and
novel treatments are urgently needed. Current therapeutic approaches for diabetic …
novel treatments are urgently needed. Current therapeutic approaches for diabetic …
[HTML][HTML] Regulation of the actin cytoskeleton in podocytes
J Blaine, J Dylewski - Cells, 2020 - mdpi.com
Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …
filtration of large proteins and macromolecules into the urine. Podocyte function is …
A potential role for mechanical forces in the detachment of podocytes and the progression of CKD
W Kriz, KV Lemley - Journal of the American Society of …, 2015 - journals.lww.com
Loss of podocytes underlies progression of CKD. Detachment of podocytes from the
glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the …
glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the …
[HTML][HTML] The podocyte's response to injury: role in proteinuria and glomerulosclerosis
SJ Shankland - Kidney international, 2006 - Elsevier
The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …
highly specialized cells. They function as a critical size and charge barrier to prevent …
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes
N Jones, IM Blasutig, V Eremina, JM Ruston, F Bladt… - Nature, 2006 - nature.com
The glomerular filtration barrier in the kidney is formed in part by a specialized intercellular
junction known as the slit diaphragm, which connects adjacent actin-based foot processes of …
junction known as the slit diaphragm, which connects adjacent actin-based foot processes of …
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria
Y Li, YS Kang, C Dai, LP Kiss, X Wen, Y Liu - The American journal of …, 2008 - Elsevier
Podocyte dysfunction plays an essential role in the pathogenesis of proteinuria and
glomerulosclerosis. However, the mechanism underlying podocyte dysfunction in many …
glomerulosclerosis. However, the mechanism underlying podocyte dysfunction in many …
The role of the podocyte in albumin filtration
In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …
[HTML][HTML] Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization
A properly established and maintained podocyte intercellular junction, or slit diaphragm, is a
necessary component of the selective permeability barrier of the kidney glomerulus. The …
necessary component of the selective permeability barrier of the kidney glomerulus. The …
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of
biological activities, including mechanosensation, osmotic homeostasis, and cell signaling …
biological activities, including mechanosensation, osmotic homeostasis, and cell signaling …
The slit diaphragm: a signaling platform to regulate podocyte function
From recent data, a novel concept of a highly dynamic slit protein complex is emerging. Slit
diaphragm proteins are contributing to the regulation of cell polarity, cell survival and …
diaphragm proteins are contributing to the regulation of cell polarity, cell survival and …