Architectures of neuronal circuits

L Luo - Science, 2021 - science.org
BACKGROUND The human brain contains about 100 billion neurons, each of which makes
thousands of synaptic connections. Although individual neurons can themselves be …

Networking brainstem and basal ganglia circuits for movement

S Arber, RM Costa - Nature Reviews Neuroscience, 2022 - nature.com
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …

Morphological diversity of single neurons in molecularly defined cell types

H Peng, P Xie, L Liu, X Kuang, Y Wang, L Qu, H Gong… - Nature, 2021 - nature.com
Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types,, yet our knowledge of its diversity remains limited. Here, to …

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

R Chen, TR Blosser, MN Djekidel, J Hao… - Nature …, 2021 - nature.com
The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and
its dysfunction has been linked to many neural disorders. However, the molecular, cellular …

[HTML][HTML] The mouse cortico–basal ganglia–thalamic network

NN Foster, J Barry, L Korobkova, L Garcia, L Gao… - Nature, 2021 - nature.com
The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in
the brain. Revealing its structural and functional organization is critical to understanding …

The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment

AA Hamid, MJ Frank, CI Moore - Cell, 2021 - cell.com
Significant evidence supports the view that dopamine shapes learning by encoding reward
prediction errors. However, it is unknown whether striatal targets receive tailored dopamine …

Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon

LE McElvain, Y Chen, JD Moore, GS Brigidi… - Neuron, 2021 - cell.com
Basal ganglia play a central role in regulating behavior, but the organization of their outputs
to other brain areas is incompletely understood. We investigate the largest output nucleus …

Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice

JM Cregg, SK Sidhu, R Leiras, O Kiehn - Nature Neuroscience, 2024 - nature.com
The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …

The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression

BR Isett, KP Nguyen, JC Schwenk, JR Yurek… - Neuron, 2023 - cell.com
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …