Functional neurological disorder (FND) is a common cause of persistent and disabling
neurological symptoms. These symptoms are varied and include abnormal control of …

The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …

Advances in omics technologies now permit the generation of highly contiguous genome
assemblies, detection of transcripts and metabolites at the level of single cells and high …

Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal
recessive early onset Parkinson's disease,. PINK1 has many unique features that enable it …

The tremendous pandemic potential of coronaviruses was demonstrated twice in the past
few decades by two global outbreaks of deadly pneumonia. The coronavirus spike (S) …

Certain obligate parasites induce complex and substantial phenotypic changes in their hosts
in ways that favor their transmission to other trophic levels. However, the mechanisms …

Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …

Mutations in the E3 ubiquitin ligase parkin (PARK2, also known as PRKN) and the protein
kinase PINK1 (also known as PARK6) are linked to autosomal-recessive juvenile …

Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most
members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin …

The production of proteins in sufficient quantity and of appropriate quality is an essential pre-
requisite for structural studies. Escherichia coli remains the dominant expression system in …