The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …

Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …

Aim This study aimed to investigate the causal impact of inflammatory cytokines on Sjogren's
Syndrome (SS) and to identify potential biomarkers for SS clinical management using …

Background Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …

Proteogenomics studies generate hypotheses on protein function and provide genetic
evidence for drug target prioritization. Most previous work has been conducted using affinity …

Objective Osteoarthritis (OA) is the most prevalent joint disease globally, serving as a
primary cause of pain and disability. However, the pathological processes underlying OA …

We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with
infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin …

Background The currently available medications for treating membranous nephropathy (MN)
still have unsatisfactory efficacy in inhibiting disease recurrence, slowing down its …

Objective The relationships between circulating inflammatory proteins and COVID-19 have
been observed in previous cohorts. However, it is not unclear which circulating inflammatory …

The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs)
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …