Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

Immunotherapy holds great promise for the treatment of aggressive and metastatic cancers;
however, currently available immunotherapeutics, such as immune checkpoint blockade …

Due to the intrinsic weak immunogenicity of tumor cells and the quantitatively and
functionally different populations of immune cells, immunosuppression has become the …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Signal transducer and activator of transcription (STAT) proteins compose a family of
transcription factors critical for cancer stem cells (CSCs), and they are involved in …

Immune effector cells in the microenvironment tend to be depleted or remodeled, unable to
perform normal functions, and even promote the malignant characterization of tumors …

RNA sensors detect foreign and endogenous RNAs to protect the host by initiating innate
and adaptive immune response. In tumor microenvironment (TME), activation of RNA …

Peptide-based vaccines, which form one of the most potent vaccine platforms, offer
exclusive advantages over classical vaccines that use whole organisms or proteins …

Lung cancer is a common malignancy worldwide, with high morbidity and mortality. Signal
transducer and activator of transcription 3 (STAT3) is an important transcription factor that …