The sirtuin family in health and disease
QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection
N D'Onofrio, L Servillo, ML Balestrieri - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …
Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
[HTML][HTML] SIRT6 in aging, metabolism, inflammation and cardiovascular diseases
Z Guo, P Li, J Ge, H Li - Aging and disease, 2022 - ncbi.nlm.nih.gov
As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
Endothelial SIRT6 is vital to prevent hypertension and associated cardiorenal injury through targeting Nkx3. 2-GATA5 signaling
J Guo, Z Wang, J Wu, M Liu, M Li, Y Sun… - Circulation …, 2019 - Am Heart Assoc
Rationale: Endothelial dysfunction is an important determinant risk factor for the
development of hypertension and its complications. Thus, identification of potential …
development of hypertension and its complications. Thus, identification of potential …
SIRT6 in senescence and aging-related cardiovascular diseases
X Li, L Liu, T Li, M Liu, Y Wang, H Ma, N Mu… - Frontiers in cell and …, 2021 - frontiersin.org
SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …
and has established diverse roles in aging, metabolism and disease. Its function is similar to …
Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
S Feng, Y Li, H Huang, H Huang, Y Duan… - European Journal of …, 2023 - Elsevier
Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …
[HTML][HTML] Cellular and molecular biology of sirtuins in cardiovascular disease
Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …
The role of post‐translational modifications in cardiac hypertrophy
K Yan, K Wang, P Li - Journal of cellular and molecular …, 2019 - Wiley Online Library
Pathological cardiac hypertrophy involves excessive protein synthesis, increased cardiac
myocyte size and ultimately the development of heart failure. Thus, pathological cardiac …
myocyte size and ultimately the development of heart failure. Thus, pathological cardiac …
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
M Vitiello, A Zullo, L Servillo, FP Mancini… - Ageing research …, 2017 - Elsevier
Abstract Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …