Advanced computational methodologies used in the discovery of new natural anticancer compounds

VP Chavda, YN Ertas, V Walhekar, D Modh… - Frontiers in …, 2021 - frontiersin.org
Natural chemical compounds have been widely investigated for their programmed necrosis
causing characteristics. One of the conventional methods for screening such compounds is …

Beneficial effects of UV radiation other than via vitamin D production

A Juzeniene, J Moan - Dermato-endocrinology, 2012 - Taylor & Francis
Most of the positive effects of solar radiation are mediated via ultraviolet-B (UVB) induced
production of vitamin D in skin. However, several other pathways may exist for the action of …

Vitamin D deficiency increases mortality risk in the UK biobank: a nonlinear mendelian randomization study

JP Sutherland, A Zhou, E Hyppönen - Annals of internal medicine, 2022 - acpjournals.org
Background: Low vitamin D status is associated with increased mortality, but randomized
trials on severely deficient participants are lacking. Objective: To assess genetic evidence …

Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer

HM Hesham, DS Lasheen… - Medicinal Research …, 2018 - Wiley Online Library
Recently, molecular hybridization paradigm became an interesting and smart way to defeat
the multifaceted cancer disease by a single molecular entity that acts via several …

Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors

AKA Bass, MS El-Zoghbi, ESM Nageeb… - European journal of …, 2021 - Elsevier
Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

Vitamin D and regulation of vascular cell function

N Jamali, CM Sorenson… - American Journal of …, 2018 - journals.physiology.org
Vitamin D deficiency is linked to pathogenesis of many diseases including cardiovascular,
cancer, and various eye diseases. In recent years, important roles for vitamin D in regulation …

The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: an update and integration of current ideas

P Jones, M Lucock, M Veysey, E Beckett - Nutrients, 2018 - mdpi.com
Vitamin D is unique in being generated in our skin following ultraviolet radiation (UVR)
exposure. Ongoing research into vitamin D must therefore always consider the influence of …

A review on regulation of cell cycle by extracellular matrix

A Rais, A Husain, GM Hasan, MI Hassan - International Journal of …, 2023 - Elsevier
The extracellular matrix (ECM) is a network of structural proteins, glycoproteins and
proteoglycans that assists independent cells in aggregating and forming highly organized …

Potential molecular mechanisms of the anti-cancer activity of vitamin D

D Skrajnowska, B Bobrowska-Korczak - Anticancer research, 2019 - ar.iiarjournals.org
Vitamin D, or more precisely its active metabolite calcitriol (1, 25-(OH) 2D3), plays a
fundamental role in bone metabolism and differentiation as well as in intestinal absorption of …

Evidence-based complementary treatment of pancreatic cancer: A review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins …

S Bigelsen - Cancer Management and Research, 2018 - Taylor & Francis
Despite new and exciting research and renewed optimism about future therapy, current
statistics of survival from pancreatic cancer remains dismal. Patients seeking alternative or …