Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to
be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a …

In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue
(VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM) …

As a metabolic organ, adipose tissue plays an important role in regulating metabolism. In
adults, most adipose tissue is white adipose tissue (WAT), and excessive expansion of WAT …

Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

The prevalence of obesity continues to rise worldwide despite evidence-based public health
recommendations. The promise to adopt a healthy lifestyle is increasingly important for …

Exercise training results in beneficial adaptations to numerous tissues and offers protection
against metabolic disorders including obesity and type 2 diabetes. Multiple studies have …

While the effect of exercise on white adipose tissue browning and metabolic improvement in
rodents is clear, there are few studies in humans with inconclusive results. Thus, the aim of …

White adipose tissue (WAT) is important for metabolic homeostasis. We established the
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …

Background Exercise exerts many health benefits by directly inducing molecular alterations
in physically utilized skeletal muscle. Molecular adaptations of subcutaneous adipose tissue …