As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …

Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative
diseases such as Alzheimer's disease and Parkinson's disease (advanced stage). Although …

MicroRNAs (miRNAs) contribute to both neuronal and immune cell fate, but their
involvement in intertissue communication remained unexplored. The brain, via vagal …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The vagus nerve can control inflammatory response through a'cholinergic anti-inflammatory
pathway', which is mediated by the α7-nicotinic acetylcholine receptor (α7nAChR) on …

Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug
development in cognitive and neuro-degenerative disorders, are allosteric proteins with …

Alzheimer's disease (AD), the major contributor to dementia in the elderly, involves
accumulation in the brain of extracellular plaques containing the β-amyloid protein (Aβ) and …

Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are
emerging as important targets for the development of novel treatments for the symptoms …

EVP-6124,(R)-7-chloro-N-quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide, is a novel
partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) that was evaluated …

A promising drug target currently under investigation to improve cognitive deficits in
neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine …