2-azidobenzaldehyde: A versatile scaffold for the generation of N-heterocyclic compounds

F Doraghi, S Karimian, SP Aledavoud, A Amini… - Journal of Molecular …, 2023 - Elsevier
Azidobenzaldehydes are a popular class of azidoaldehydes that have been recognized as
readily available, highly stable, commercially accessible starting materials. Owing to the …

A series of 1, 2, 3-triazole compounds: Synthesis, characterization, and investigation of the cholinesterase inhibitory properties via in vitro and in silico studies

A Tan, Z Almaz - Journal of Molecular Structure, 2023 - Elsevier
Abstract A series of 1, 2, 3-triazole compounds derived from a salicylaldehyde moiety were
synthesized in high yields using copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) …

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease

N Szałaj, J Godyń, J Jończyk, A Pasieka… - Journal of Enzyme …, 2020 - Taylor & Francis
Effective therapy of Alzheimer's disease (AD) requires treatment with a combination of drugs
that modulate various pathomechanisms contributing to the disease. In our research, we …

Development of bisindole-substituted aminopyrazoles as novel GSK-3β inhibitors with suppressive effects against microglial inflammation and oxidative neurotoxicity

JG Liu, D Zhao, Q Gong, F Bao, WW Chen… - ACS Chemical …, 2020 - ACS Publications
Development of glycogen synthase kinase-3β (GSK-3β) inactivation-centric agents with
polypharmacological profiles is increasingly recognized as a promising therapeutic strategy …

Investigation of biological activities of various 1, 2, 3‐triazole compounds: Their effects on cholinesterase enzymes, determination of antioxidant capacity and …

Z Almaz - Journal of Biochemical and Molecular Toxicology, 2023 - Wiley Online Library
triazoles are pharmaceutically significant compounds that have attracted recent interest from
medicinal chemists because of their important biological activities. Addressed herein, some …

Synthesis of 4-Arylselanyl-1H-1,2,3-triazoles from Selenium-Containing Carbinols

F Begini, RA Balaguez, A Larroza, EF Lopes… - Molecules, 2021 - mdpi.com
In this work, we present a simple way to achieve 4-arylselanyl-1 H-1, 2, 3-triazoles from
selenium-containing carbinols in a one-pot strategy. The selenium-containing carbinols …

Synthesis of α‐Hydroxyphosphonates Containing Functionalized 1,2,3‐Triazoles

YR Lima, GP Da Costa, MCDF Xavier… - …, 2020 - Wiley Online Library
Herein, we described a simple and efficient protocol for the synthesis of α‐
hydroxyphosphonates containing 1, 2, 3‐triazole moiety in their structures under mild …

Cu‐Catalyzed Cross‐Coupling Reactions of Enamines and Terminal Alkynes: Access of Propargylamines as Neurodegenerative Disorder Agents

L Mohan, JE Lee, M Srinivasarao… - Asian Journal of …, 2023 - Wiley Online Library
Reactions between enamine analogues and terminal alkynes were explored. Copper (I)
complex of 1, 10‐phenanthroline catalyzed these reactions to generate a diastereoselective …

Synthesis of 2′-(1, 2, 3-triazoyl)-acetophenones: molecular docking and inhibition of in vitro monoamine oxidase activity

GP Costa, ÍFC Dias, MG Fronza, EM Besckow… - New Journal of …, 2021 - pubs.rsc.org
We describe our results for the synthesis of 2′-(1, 2, 3-triazoyl)-acetophenones by copper
catalyzed azide–alkyne cycloaddition of 2′-azidoacetophenone with alkynes. The …

1, 2, 3-triazole based conjugates-potential cholinesterase (AChE and BuChE) and BACE inhibitors for treatment of Alzheimer

R Singh, H Kaur, P Gupta - AIP Conference Proceedings, 2023 - pubs.aip.org
Alzheimer's disease (AD) is an intricate neurological disorder in which degeneration of brain
cells occurs. A recent study has demonstrated that around thirty-six million people are …