The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance
and it responds to various cell stresses that oxidative stress is the most well-known one. The …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and
its molecular mechanism is urgently needed. Studies have shown that the intestinal flora …

Inflammation plays an important role in the pathophysiology of cardiometabolic diseases.
Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP) …

Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1 is a unique,
understudied member of the Nod-like Receptor (NLR) family of pattern recognition receptors …

Ischemic cardiomyopathy (ICM) caused by coronary artery disease always leads to
myocardial infarction and heart failure. Identification of novel transcriptional regulators in …

Ischemic cardiomyopathy (ICM), which increases along with aging, is the leading cause of
heart failure. Currently, immune response is believed to be critical in ICM whereas the roles …

Decreased nicotinamide adenine dinucleotide (NAD+) levels contribute to various
pathologies such as ageing, diabetes, heart failure and ischemia–reperfusion injury (IRI) …

Prior studies have defined multiple, but inconsistent, roles for the enigmatic pattern
recognition receptor NLRX1 in regulating several cancer-associated biological functions. In …

Abstract Background Dexmedetomidine (Dex) is a safe and effective anesthetic adjunct
which also has neuroprotective roles. This study aimed to validate the role of Dex in hypoxic …