Syphilis trends among men who have sex with men in the United States and Western Europe: a systematic review of trend studies published between 2004 and 2015

WE Abara, KL Hess, R Neblett Fanfair, KT Bernstein… - PloS one, 2016 - journals.plos.org
Globally, men who have sex with men (MSM) are disproportionately burdened with syphilis.
This review describes the published literature on trends in syphilis infections among MSM in …

Evidence and knowledge gaps on the disease burden in sexual and gender minorities: a review of systematic reviews

K Blondeel, L Say, D Chou, I Toskin, R Khosla… - International journal for …, 2016 - Springer
Sexual and gender minorities (SGM) include individuals with a wide range of sexual
orientations, physical characteristics, and gender identities and expressions. Data suggest …

Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study

LC Tantalo, NAP Lieberman, C Pérez-Mañá… - The Lancet …, 2023 - thelancet.com
Background The increasing incidence of syphilis and the limitations of first-line treatment
with penicillin, particularly in neurosyphilis, neonatal syphilis, and pregnancy, highlight the …

Genetic engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete

E Romeis, L Tantalo, N Lieberman, Q Phung… - PLoS …, 2021 - journals.plos.org
Despite more than a century of research, genetic manipulation of Treponema pallidum
subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful. The …

Current status of syphilis vaccine development: need, challenges, prospects

CE Cameron, SA Lukehart - Vaccine, 2014 - Elsevier
Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum
subsp. pallidum. Despite inexpensive and effective antibiotic therapy, syphilis remains a …

Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus–infected men: results from the FHDH-ANRS CO4 cohort

W Jarzebowski, E Caumes, N Dupin… - Archives of internal …, 2012 - jamanetwork.com
Background Concomitant syphilis and human immunodeficiency virus (HIV) infection is
increasingly frequent in industrialized countries. Methods From a large hospital cohort of HIV …

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study.

F Sarıgül, M Sayan, D İnan, A Deveci… - … European journal of …, 2019 - gcris.pau.edu.tr
OBJECTIVE: Treponema pallidum and HIV are transmitted frequently through sexual
contact, these agents with epidemiological similarities co-infect the same host. The current …

Lymphogranuloma venereum in Europe, 2003-2008

EJ Savage, MJ Van de Laar, A Gallay… - …, 2009 - eurosurveillance.org
Lymphogranuloma venereum, caused by the L serovars of Chlamydia trachomatis, emerged
in Europe in 2003 and a series of outbreaks were reported in different countries. The …

Vaccine development for syphilis

KV Lithgow, CE Cameron - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum,
continues to be a globally prevalent disease despite remaining susceptible to penicillin …

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune …

MJ Lin, AM Haynes, A Addetia… - PLoS Neglected …, 2021 - journals.plos.org
Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been
attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino …