Background Radioresistance is a major factor leading to the failure of radiotherapy and poor
prognosis in tumor patients. Following the application of radiotherapy, the activity of various …

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a
larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of …

Regulatory T (Treg) cells play a vital role in maintaining the immunosuppressive tumor
microenvironment. Lactate is a crucial metabolite in cancer and is related to tumor …

Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …

Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

As cancers progress, they produce a local environment that acts to redirect, paralyze,
exhaust, or otherwise evade immune detection and destruction. The tumor …

Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) play
critical roles in tumorigenesis. However, the mechanisms underlying MDSC and TAM …

Genetically engineered microbes, especially Escherichia coli, have been widely used in the
biosynthesis of proteins and metabolites for medical and industrial applications. As a …

Radiotherapy is a regimen that uses ionising radiation (IR) to treat cancer. Despite the
availability of several therapeutic options, cancer remains difficult to treat and only a minor …

Increasing body of evidence suggests that there exists a connection between diabetes and
cancer. Nevertheless, to date, the potential reasons for this association are still poorly …