Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …

Embryonic development requires tight control of gene expression levels, activity, and
localisation. This control is coordinated by multiple levels of regulation on DNA, RNA and …

Circular RNAs (circRNAs) are critical regulators in the occurrence and development of
numerous cancers, in which abnormal autophagy plays a key role. However, the potential …

Recognition of single-stranded RNA (ssRNA) by RNA recognition motif (RRM) domains is
an important class of protein–RNA interactions. Many such complexes were characterized …

The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …

Most cellular processes are carried out by protein complexes, but it is still largely unknown
how the subunits of lowly expressed complexes find each other in the crowded cellular …

Innate immune response is triggered by pathogen components, like lipopolysaccharides
(LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which …