purpose. The angiopoietin (Ang) system plays an important role in vascular stabilization and
pathologic neovascularization. The hypothesis for the study was that, in addition to …

The field of tissue engineering seeks to create metabolically demanding, functional tissues,
which will require blood vessel networks capable of forming rapidly in a variety of …

Ischemia-induced acute renal failure (ARF) is a disorder with high morbidity and mortality.
ARF is characterized by a regeneration phase, yet its molecular basis is still under study …

The receptor tyrosine kinase Tie2 is highly expressed in endothelial cells and is crucial for
angiogenesis and vascular maintenance. The ligands for Tie2 are the angiopoietins, of …

Patients with psoriasis have systemic and vascular inflammation and are at increased risk
for myocardial infarction, stroke, and cardiovascular death. However, the underlying …

Vasculogenesis and angiogenesis are the fundamental processes by which new blood
vessels are formed. Vasculogenesis is defined as the differentiation of endothelial precursor …

Despite 2 decades of research, no clear function for annexin A1 (AnxA1) has been
established. Using AnxA1-KO mice, we show that tumor growth and metastasis are …

The angiopoietin (Ang)/Tie2 system is exclusively involved in vasculogenesis and
angiogenesis. Ang2 is known to inhibit Ang1-mediated phosphorylation of Tie2 as well as …

The expansion or remodelling of pre-existing blood vessels, known as angiogenesis, by
either nascent sprouting, intercalated or intussusceptive growth is a highly regulated …

Prostate cancer bone metastasis remains lethal and incurable, and often arises years after
elimination of the primary tumor. It is unclear what underlies the decades-long clinical …