Background There is ongoing debate regarding the initiation of psoriatic plaque as primarily
arising from an anomaly in epidermal keratinocytes (KCs) or from abnormalities in …

Recovery from acute renal failure (ARF) requires the replacement of injured cells with new
cells that restore tubule epithelial integrity. We described recently the expression of a wide …

Psoriasis is a common, persistent skin disorder characterized by recurrent erythematous
lesions thought to arise as a result of inflammatory cell infiltration and activation of …

Abstract The angiopoietin (Ang)/Tie2 system is implicated in blood vessel formation and
maturation. However, the mitogenic effects of angiopoietins remain to be elucidated. Here …

Malignant gliomas are the prototype of highly infiltrative tumors and this characteristic is the
main factor for the inevitable tumor recurrence and short survival after most aggressive …

We explored the physiologic role of endothelial cell apoptosis during development by
generating mouse embryos lacking the inhibitor of apoptosis protein (IAP) survivin in …

Angiopoietin-1/Tie2 (ANG1/Tie2) signaling is well documented as regulating angiogenesis
and vessel maturation. This pathway is complicated by involvement of the orphan receptor …

Early theories of tumor angiogenesis suggested that preexisting vessels surrounding the
tumor were the principal source of the tumor vasculature but recent evidence suggests that …

The interaction between the vascular endothelium and hemodynamic forces (and more
specifically, fluid shear stress), induced by the flow of blood, plays a major role in vascular …

Activated protein C (APC) is a natural anticoagulant with strong anti-inflammatory, anti-
apoptotic, and barrier stabilizing properties. These cytoprotective properties of APC are …