Objectives The endothelial cell (EC)-selective receptor tyrosine kinase, Tie2, and its ligands
angiopoietin Ang-1 and Ang-2, are essential for blood vessel maintenance and repair. Ang …

The basic science and development of therapies targeting the blood vascular system has
enjoyed much focus due to the knowledge of the molecular mechanisms behind its …

Background Earlier studies by our group have demonstrated that a transgenic animal
engineered to express Tie2 under the control of the Tie2 promoter produced animals with a …

Angiopoietin-1 (Ang1) and Ang2 regulate the maintenance of normal vasculature by direct
endothelial and indirect smooth muscle cell (SMC) effects. Dysfunction of vascular wall cells …

Tie2 is an endothelium-specific receptor tyrosine kinase required for normal blood vessel
maturation. We report that Tie2 mRNA translation is maintained under hypoxic conditions …

Motivation: Data mining tools are proposed to establish mechanistic connections between
chemotypes and specific cellular functions. Drawing on a previous study that classified the …

VEGF and Angiopoietin (Ang) 1 are growth factors that independently improve wound
healing outcomes. Using a tet-repressible mouse model coupled with streptozotocin …

Background Non‐invasive methods are desirable for longitudinal studies examining drug
efficacy and disease resolution defined as decreases in epidermal thickness in mouse …

The role of apoptosis in the formation and regression of neovascularization is largely
hypothesized, although the detailed mechanism remains unclear. Inflammatory cells and …

В обзоре рассмотрен вопрос о связи селективности ингибиторов киназ Bcr-Abl со
спектром нежелательных побочных эффектов у больных хроническим миелолейкозом …