Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

Cancer therapy-related cardiac dysfunction (CTRCD) is one of the most feared and
undesirable side effects of chemotherapy, occurring in approximately 10% of the patients. It …

Cancer diagnostics and therapies have improved steadily over the last few decades,
markedly increasing life expectancy for patients at all ages. However, conventional and …

АВ—атриовентрикулярный (ая) АГ—артериальная гипертензия АД—артериальное
давление АТ—артериальный тромбоз АТО—атеротромботические осложнения АТФ …

Doxorubicin is an effective anti-tumor agent with a cumulative dose-dependent
cardiotoxicity. In addition to its principal toxic mechanisms involving iron and redox …

Chemotherapy with anthracycline-based regimens remains a cornerstone of treatment of
many solid and blood tumors but is associated with a significant risk of cardiotoxicity, which …

Success with oncologic treatment has allowed cancer patients to experience longer cancer-
free survival gains. Unfortunately, this success has been tempered by unintended and often …

Few millions of new cancer cases are diagnosed worldwide every year. Due to significant
progress in understanding cancer biology and developing new therapies, the mortality rates …

Doxorubicin is a highly effective anticancer chemotherapy agent, but its use is limited by its
cardiotoxicity. To develop a drug that prevents this toxicity, we established a doxorubicin …

Shengxian Decotion (SXT), a well-known Traditional Chinese Medicine (TCM) formula
composed of Astragali Radix, Bupleuri Radix, Cimicifugae Rhizoma, Anemarrhenae …