Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

GCaMP, one popular type of genetically-encoded Ca2+ indicator, has been associated with
various side-effects. Here we unveil the intrinsic problem prevailing over different versions …

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

Local Ca2+ signaling occurring within nanometers of voltage-gated Ca2+ (Cav) channels is
crucial for CNS function, yet the molecular composition of Cav channel nano-environments …

Recent work has identified missense mutations in calmodulin (CaM) that are associated with
severe early-onset long-QT syndrome (LQTS), leading to the proposition that altered CaM …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

Maleimide-cysteine chemistry has been a routine practice for the site-specific labeling of
fluorophores to proteins since the 1950s. This approach, however, cannot bring out the best …

Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …