Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a
prototypic inflammatory disease, affecting the small joints of the hands and feet. Chemokines …

Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family of
cytokines that mediate leukocyte chemotaxis. The potent and specific activation of …

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the
molecules that induce and regulate immune responses. Now expanded to two volumes, co …

Migration of leukocytes from the bone marrow to the circulation, the primary lymphoid organs
and inflammatory sites is directed by chemokines and specific receptor interactions. Besides …

Objective To elucidate the role of microRNA (miRNA) in the pathogenesis of rheumatoid
arthritis (RA), we analyzed synoviocytes from RA patients for their miRNA expression …

Abstract Objective Interleukin‐22 (IL‐22) is a novel cytokine of the IL‐10 family. Although its
pathophysiologic function is largely unknown, induction of acute‐phase responses by IL‐22 …

Two novel polymorphisms in the distal regulatory region of the MCP-1 gene were identified
by directly sequencing PCR amplified genomic DNA. These polymorphisms are located at …

Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

Chemokine signaling plays an important role in the postischemic inflammatory response.
Overlapping pathways involving reactive oxygen intermediates, Toll-like receptor (TLR) …

Interleukin‐8 has long been recognized to have anti‐inflammatory activity, which has been
established in various models of infection, inflammation, and cancer. Several cell types …