Recent genome-wide association studies (GWAS) have identified DNA sequence variations
that exhibit unequivocal statistical associations with many common chronic diseases …

Objective To verify the hypothesis that in rheumatoid arthritis (RA), tumor necrosis factor α
(TNFα) plays a critical role in regulating leukocyte trafficking and chemokine levels. Methods …

Introduction Rheumatoid arthritis (RA) is a T-cell-mediated systemic autoimmune disease,
characterized by synovium inflammation and articular destruction. Bone marrow …

The appearance of specific types of leukocytes in inflammatory infiltrates may be governed
by cell-specific chemoaatractants called chemokines. In particular, monocyte …

The pathogenesis of rheumatoid arthritis (RA) may be mediated by Th1-type T cells. Since
chemokine receptors CXCR3 and CCR5 are preferentially expressed on Th1 cells, we …

An antagonist of human monocyte chemoattractant protein (MCP)-1, which consists of MCP-
1 (9-76), had previously been characterized and shown to inhibit MCP-1 activity in vitro. To …

Objective Since it is likely that monocytes utilize chemokines to migrate to the rheumatoid
arthritis (RA) joint, we investigated the expression of C‐C chemokine receptors (CCR) 1–6 …

RA is characterized by a systemic inflammatory state, in which immune cells and soluble
mediators play a crucial role. These inflammatory processes resemble those in other chronic …

Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The
influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that …

Chemokines and chemokine receptors are involved in leukocyte recruitment and
angiogenesis underlying the pathogenesis of rheumatoid arthritis (RA) and other …