Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis
YB Sun, H Zhao, DL Mu, W Zhang, J Cui, L Wu… - Cell Death & …, 2019 - nature.com
Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α2-
adrenoceptor agonist, has been reported to possess neuroprotective effects against various …
adrenoceptor agonist, has been reported to possess neuroprotective effects against various …
Activated mesenchymal stem cells interact with antibiotics and host innate immune responses to control chronic bacterial infections
V Johnson, T Webb, A Norman, J Coy, J Kurihara… - Scientific reports, 2017 - nature.com
Chronic bacterial infections associated with biofilm formation are often difficult to resolve
without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert …
without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert …
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism
Z Hu, T Murakami, K Suzuki, H Tamura… - PloS one, 2014 - journals.plos.org
Pyroptosis is a caspase-1 dependent cell death, associated with proinflammatory cytokine
production, and is considered to play a crucial role in sepsis. Pyroptosis is induced by the …
production, and is considered to play a crucial role in sepsis. Pyroptosis is induced by the …
Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis
L Liu, K Xie, H Chen, X Dong, Y Li, Y Yu, G Wang, Y Yu - Brain research, 2014 - Elsevier
During the development of sepsis, the complication in central nervous system (CNS),
appearing early and frequently relative to other systems, can obviously increase the …
appearing early and frequently relative to other systems, can obviously increase the …
[HTML][HTML] The activation of IL-17 signaling pathway promotes pyroptosis in pneumonia-induced sepsis
LL Li, B Dai, YH Sun, TT Zhang - Annals of Translational Medicine, 2020 - ncbi.nlm.nih.gov
Background Pyroptosis is closely relevant to sepsis. However, the molecular mechanisms of
pyroptosis in pneumonia-induced sepsis are still not fully understood. Thus, this study aimed …
pyroptosis in pneumonia-induced sepsis are still not fully understood. Thus, this study aimed …
[HTML][HTML] Dexmedetomidine prevents septic myocardial dysfunction in rats via activation of α7nAChR and PI3K/Akt-mediated autophagy
T Yu, D Liu, M Gao, P Yang, M Zhang, F Song… - Biomedicine & …, 2019 - Elsevier
Abstract Background and purpose Dexmedetomidine (Dex) has been shown to elicit cardio-
protective effects in sepsis. The aim of this study was to investigate the role of autophagy in …
protective effects in sepsis. The aim of this study was to investigate the role of autophagy in …
The pathophysiology of sepsis-associated AKI
S Kuwabara, E Goggins, MD Okusa - Clinical Journal of the …, 2022 - journals.lww.com
Sepsis-associated AKI is a life-threatening complication that is associated with high
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …
morbidity and mortality in patients who are critically ill. Although it is clear early supportive …
Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me'signals: cleavage and inhibition of phagocytosis by Lp …
VA Tyurin, K Balasubramanian, D Winnica… - Cell Death & …, 2014 - nature.com
Diversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of
apoptotic cells are universal phagocytic signals. However, the role of major PS metabolites …
apoptotic cells are universal phagocytic signals. However, the role of major PS metabolites …
Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats
PH Sung, CL Chang, TH Tsai, LT Chang, S Leu… - Stem cell research & …, 2013 - Springer
Introduction We tested the hypothesis that apoptotic adipose-derived mesenchymal stem
cells (A-ADMSC) are superior to healthy (H)-ADMSC in attenuating cecal ligation puncture …
cells (A-ADMSC) are superior to healthy (H)-ADMSC in attenuating cecal ligation puncture …