The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Skin is the largest organ of the body with important protective functions, which become
compromised with time due to both intrinsic and extrinsic ageing processes. Cellular …

Abstract Alzheimer's disease (AD), the most prominent form of dementia in the elderly, has
no cure. Strategies focused on the reduction of amyloid beta or hyperphosphorylated Tau …

Heterocycles are common in the structure of drugs used clinically to deal with diseases.
Such drugs usually contain nitrogen, oxygen and sulfur, which possess electron-accepting …

Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in
the AMP: ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in …

Alzheimer's disease (AD) has no cure. Earlier, we showed that partial inhibition of
mitochondrial complex I (MCI) with the small molecule CP2 induces an adaptive stress …

The elderly proportion of the population is gradually increasing, which poses a great burden
to society, the economy, and the medical field. Aging is a physiological process involving …

Adipose tissue is a widely distributed organ that plays a critical role in age-related
physiological dysfunctions as an important source of chronic sterile low-grade inflammation …