Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …

Critical illness caused by burn and sepsis is associated with pathophysiologic changes that
may result in the alteration of pharmacokinetics (PK) of antibiotics. However, it is unclear if …

Abstract Background and Objective Piperacillin is a broad-spectrum β-lactam antibiotic
commonly prescribed in intensive care units. Many piperacillin population pharmacokinetic …

Abstract Background and Objective Piperacillin/tazobactam is one of the most frequently
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …