Innate resistance to Candida albicans in mucosal tissues requires the production of
interleukin-17A (IL-17A) by tissue-resident cells early during infection, but the mechanism of …

Primary headaches such as migraine are postulated to involve the activation of sensory
trigeminal pain neurons that innervate intracranial blood vessels and the dura mater. It is …

Recent findings indicate that nociceptive nerves are not “free”, but similar to touch and
pressure sensitive nerves, terminate in an end-organ in mice. This sensory structure consists …

Autonomic dysreflexia (AD) and neuropathic pain occur after severe injury to higher levels of
the spinal cord. Mechanisms underlying these problems have rarely been integrated in …

Long-term potentiation in the spinal dorsal horn requires peptidergic C-fibre activation in
animals. Perceptual correlates of long-term potentiation following high-frequency electrical …

Significance: Diabetic peripheral neuropathy (DPN), a complication of metabolic syndrome,
type I and type II diabetes, leads to sensory changes that include slow nerve conduction …

Cutaneous somatosensory neurons convey innocuous and noxious mechanical, thermal,
and chemical stimuli from peripheral tissues to the CNS. Among these are nociceptive …

Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease.
We tested whether this parameter and tactile allodynia, the standard pain measure in …

Diabetic-induced peripheral neuropathy (DPN) is a highly complex and frequent diabetic
late complication, which is manifested by prolonged hyperglycemia. However, the molecular …

Urinary tract infections (UTIs) account for almost 25% of infections in women. Many are
recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary …