To account for the complex genetics, the developmental biology, and the late
adolescent/early adulthood onset of schizophrenia, the “two-hit” hypothesis has gained …

DiGeorge syndrome, velocardiofacial syndrome and various other malformations have been
described in association with deletions and translocations involving human chromosome …

Summary Background Del22q11. 2 syndrome is the most frequent known chromosomal
microdeletion syndrome, with an incidence of 1 in 4000–5000 livebirths. It is characterised …

DiGeorge syndrome is characterized by cardiovascular, thymus and parathyroid defects and
craniofacial anomalies, and is usually caused by a heterozygous deletion of chromosomal …

22q11. 2 deletion syndrome (22q11. 2DS) is a disorder caused by recurrent, chromosome‐
specific, low copy repeat (LCR)–mediated copy‐number losses of chromosome 22q11. The …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …

The 22q11. 2 deletion syndrome, which includes DiGeorge and velocardiofacial syndromes
(DGS/VCFS), is the most common microdeletion syndrome. The majority of deleted patients …

This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …

Individuals with 22q11. 2 deletion syndrome (22q11. 2DS) can present with a wide range of
features that are highly variable, even within families. The major clinical manifestations of …

Appropriate interactions between the epithelium and adjacent neural crest-derived
mesenchyme are necessary for normal pharyngeal arch development. Disruption of …