Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure,
as a result of genetic defects, and after trauma or acute lung injury leading to …

Mesenchymal stem cells (MSCs) and regulatory T cells (Tregs) are both potent immune-
modulators. The aberrant proliferation and function of Tregs plays an important role in the …

Radiation therapy has curative or palliative potential in roughly half of all incident solid
tumours, and offers organ and function preservation in most cases. Unfortunately, early and …

Several studies have demonstrated that mesenchymal stem cells have the capacity to
reverse acute and chronic kidney injury in different experimental models by paracrine …

Human pulmonary fibrosis is characterized by alveolar epithelial cell injury, areas of type II
cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …

We sought to determine whether an intact bone marrow is essential to lung repair following
bleomycin-induced lung injury in mice, and the mechanisms of any protective effects …

Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+(CD45+
Col I+ CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have …

Reactive stroma initiates during early prostate cancer development and coevolves with
prostate cancer progression. Previous studies have defined the key markers of reactive …

Tissue fibrosis is a major cause of morbidity, and idiopathic pulmonary fibrosis (IPF) is a
terminal illness characterized by unremitting matrix deposition in the lung. The mechanisms …