Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …

The inflammasome is hypothesized to be a key mediator of the response to physiological
and psychological stressors, and its dysregulation may be implicated in major depressive …

Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Intracerebral hemorrhage (ICH) is one of the most lethal stroke subtypes. Despite the high
morbidity and mortality associated with ICH, its pathophysiology has not been investigated …

Preclinical studies have attributed neuroprotective properties to the antibiotic minocycline.
Animal studies and early clinical trials support its use in several neurological diseases. In …

Psychological stress contributes to the development of clinical depression. This has
prompted many preclinical studies to investigate the neurobiology of this relationship …

Background On the basis of encouraging preliminary results, we conducted a randomized,
controlled trial to determine whether minocycline reduces the risk of conversion from a first …

Biological barriers are essential for the maintenance of homeostasis in health and disease.
Breakdown of the intestinal barrier is an essential aspect of the pathophysiology of …