The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Pertussis (whooping cough) is a respiratory disease caused primarily by Bordetella
pertussis, a Gram-negative bacteria. Pertussis is a relatively contagious infectious disease in …

Introduction Whole cell and acellular pertussis vaccines have been very effective in
decreasing the deaths of neonates and infants from Bordetella pertussis. Despite high …

Pertussis toxin (PT) is considered the main virulence factor causing whooping cough or
pertussis. The protein is widely studied and its composition was revealed and sequenced …

Introduction Recombinant acellular pertussis (ap) vaccines containing genetically
inactivated pertussis toxin (PT gen) and filamentous hemagglutinin (FHA) with or without …

Background Recombinant pertussis vaccines inducing long-lasting immune responses
could help to control the rise in pertussis. We here report on persisting antibody responses 2 …

Background The immunogenicity of acellular pertussis vaccines and persistence of immunity
after vaccination might be improved by using genetically inactivated pertussis toxin (PTgen) …

Effective diphtheria, tetanus toxoids, whole-cell pertussis (wP) vaccines were used for
massive immunization in the 1950s. The broad use of these vaccines significantly reduced …

Background Increasing evidence shows that protection induced by acellular pertussis
vaccines is short-lived, requiring repeated booster vaccination to control pertussis disease …

Whooping cough is caused by the bacterium Bordetella pertussis. There are currently two
types of vaccines that can prevent the disease; whole cell vaccines (WCV) and acellular …