Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Ferroptosis is a newly defined form of cell death induced by iron-dependent accumulation of
lethal lipid peroxidation. Ferroptosis represent a therapeutic strategy to suppress therapy …

Airway remodeling is one of the characteristics for chronic obstructive pulmonary disease
(COPD). The mechanism underlying airway remodeling is associated with epithelial …

Over decades of studies, accumulating evidence has suggested that epigenetic
dysregulation is a hallmark of tumours. Post-translational modifications of histones are …

Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …

Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide
adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is …

The epithelial to mesenchymal transition (EMT) is a cellular process that has been linked to
the promotion of aggressive cellular features in many cancer types. It is characterized by the …

Ferroptosis differs from traditional cell death mechanisms like apoptosis, necrosis, and
autophagy, primarily due to its reliance on iron metabolism and the loss of glutathione …

Ion channels have recently emerged as stable biomarkers and anticancer targets
particularly when the applications of the currently available therapeutic regimens are limited …