Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

Due to their permanent and close proximity to neurons, glial cells perform essential tasks for
the normal physiology of the retina. Astrocytes and Müller cells (retinal macroglia) provide …

Glaucoma is the second leading cause of blindness worldwide, affecting~ 80 million people
by 2020 (,). The condition is characterized by a progressive loss of retinal ganglion cells …

Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma,
the leading cause of irreversible blindness. Here, we used RNA-sequencing and …

Glaucoma, a progressive degenerative condition that results in the death of retinal ganglion
cells, is one of the leading causes of blindness, affecting millions worldwide. The …

Retinal ganglion cells (RGCs) are a population of neurons of the central nervous system
(CNS) extending with their soma to the inner retina and with their axons to the optic nerve …

Nicotinamide adenine dinucleotide (NAD) is a key molecule in several cellular processes
and is essential for healthy mitochondrial metabolism. We recently reported that …

The central nervous system (CNS) regulates and coordinates an extensive array of complex
processes requiring harmonious regulation of specific genes. CNS disorders represent a …

Abstract Ischemia-reperfusion (I/R) injury is a common pathological mechanism in many
retinal diseases, which can lead to cell death via mitochondrial dysfunction. Voltage …

Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing
intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the …